Doing business pursuant to the principles of Corporate Social Responsibility (CSR) is a winning strategy for enterprises which want to establish a balance between achieving the main goal of the enterprise - financial result and fulfilment of employees, clients and community needs, as well as the needs of the whole society. The goal of this research was to analyze the application of DOP based on the UN Global Compact principles in the company Croatian Postal Bank, Plc. (HPB) in order to achieve the understanding of the necessity and importance of DOP’s. For drafting this essay, secondary data and information sources were used. Acquiring data from secondary sources was based on analyzing the content of science and professional papers, relevant literature and documentation of the selected enterprise, which is available on the Internet. Research results show that HPB, as the leading bank in domestic ownership and an important subject on Croatian market, upholds the ten UN Global Compact initiative principles, in four areas. In the area of human rights activities are performed in the field of information security in business activities, in the field of protection, education and concern for all employees. The Bank has a Regulation on the Procedures and Measures of Protection of Dignity and Discrimination Protection of its employees. In the area of working conditions, Collective Agreement regulates employees’ rights above legally prescribed minimum. HPB manages employees with quality, performs legal inquiries regarding employees’ health, takes care on work place quality improvement and performs work safety educations. In the field of environmental protection, through its business activity, HPB supports a greater responsibility towards the environment, development and dissemination of technologies, which are environmental-friendly. By means of the Green office, activities are performed with the purpose of reduction of negative influences on the environment, saving of energy products and adequate disposal of electronic waste. In the area of anti-corruption, HPB systematically supports through its activities the policy of preventing bribe and corruption, as well as the policy of preventing money laundering and financing of terrorism.